G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

Trends Biochem Sci. 1995 Apr;20(4):151-6. doi: 10.1016/s0968-0004(00)88992-6.


G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Blood Proteins / metabolism
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Phosphoproteins*
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction
  • ras Proteins / metabolism


  • Blood Proteins
  • Phosphoproteins
  • platelet protein P47
  • Receptor Protein-Tyrosine Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • GTP-Binding Proteins
  • ras Proteins