Clinical factors associated with urinary albumin excretion in type II diabetes

Am J Kidney Dis. 1995 Jun;25(6):836-44. doi: 10.1016/0272-6386(95)90565-0.

Abstract

Clinical factors associated with urinary albumin excretion (UAE) in type II diabetes are less well known than in type I diabetes. To examine the factors associated with UAE in type II diabetes, 933 Appropriate Blood Pressure Control in Diabetes Trial patients were classified according to UAE status: normoalbuminuria (< 20 micrograms/min), microalbuminuria (20 to 200 micrograms/min), and macroalbuminuria (> 200 micrograms/min). The class of UAE was then correlated with various clinical factors. Using univariate analyses, Hispanic ethnicity, African-American race, male gender, poor glycemic control, insulin use, long duration of diabetes, dyslipidemia, diastolic and systolic hypertension, smoking, and obesity were significantly correlated with microalbuminuria and macroalbuminuria. Using multivariate logistic regression analyses controlling for diabetes duration, glycosylated hemoglobin, gender, and race, the most significant predictors of microalbuminuria and macroalbuminuria were systolic hypertension, body mass index, high-density lipoprotein cholesterol, insulin use, and smoking pack-years. Of these factors, several are potentially reversible with aggressive intervention.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albuminuria / epidemiology
  • Albuminuria / etiology*
  • Albuminuria / prevention & control
  • Antihypertensive Agents / therapeutic use
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetic Angiopathies / drug therapy
  • Diabetic Nephropathies / epidemiology
  • Diabetic Nephropathies / etiology*
  • Diabetic Nephropathies / prevention & control
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Hypertension / drug therapy
  • Logistic Models
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Smoking / epidemiology

Substances

  • Antihypertensive Agents