Common variable immunodeficiency in a renal transplant patient with severe recurrent bacterial infection: a case report and review of the literature

Am J Kidney Dis. 1995 Jun;25(6):947-51. doi: 10.1016/0272-6386(95)90580-4.


The second reported case of common variable immunodeficiency (acquired agammaglobulinemia) after renal transplantation is presented. Agammaglobulinemia presumably resulted from long-standing immunosuppression. This case and our review of the literature indicate that agammaglobulinemia is a rare event after transplantation but can be treated successfully with intravenous immunoglobulin. Additionally, hypogammaglobulinemia occurs frequently after transplantation and should be monitored and treated in appropriate clinical situations. The treatment of our patient with intravenous immunoglobulin also suggests that patients with common variable immunodeficiency can undergo renal transplantation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Azathioprine / adverse effects*
  • Azathioprine / therapeutic use
  • Common Variable Immunodeficiency / etiology*
  • Common Variable Immunodeficiency / immunology
  • Common Variable Immunodeficiency / therapy
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunosuppression Therapy / adverse effects*
  • Kidney Transplantation / immunology*
  • Male
  • Pneumonia, Pneumococcal / immunology*
  • Recurrence


  • Immunoglobulins, Intravenous
  • Azathioprine