Treatment of experimental frostbite with pentoxifylline and aloe vera cream

Arch Otolaryngol Head Neck Surg. 1995 Jun;121(6):678-80. doi: 10.1001/archotol.1995.01890060076015.


Objective: To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite.

Design: The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline.

Main outcome measures: Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks.

Results: The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%).

Conclusion: Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Aloe*
  • Animals
  • Drug Therapy, Combination
  • Frostbite / drug therapy*
  • Male
  • Ointments
  • Pentoxifylline / administration & dosage
  • Pentoxifylline / therapeutic use*
  • Plants, Medicinal*
  • Rabbits
  • Tissue Survival / drug effects


  • Ointments
  • Pentoxifylline