A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis

Biosystems. 1995;35(1):83-92. doi: 10.1016/0303-2647(94)01484-o.


We propose a dynamical model for the hypothalamo-pituitary-thyroid axis. This model takes into account both the interactions of hormones in this axis and the binding of thyroid hormones with proteins in plasma and tissues. It can account for the pulsatile character of hormone secretion in this axis as well as many experimental results.

MeSH terms

  • Animals
  • Feedback
  • Humans
  • Hypothalamic Hormones / metabolism
  • Hypothalamo-Hypophyseal System / metabolism*
  • Hypothalamo-Hypophyseal System / physiology
  • Mathematics
  • Models, Biological*
  • Pituitary Hormones / metabolism
  • Protein Binding
  • Thyroid Gland / metabolism*
  • Thyroid Gland / physiology
  • Thyroid Hormones / metabolism


  • Hypothalamic Hormones
  • Pituitary Hormones
  • Thyroid Hormones