A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis

G Li; B Liu; Y Liu

doi:10.1016/0303-2647(94)01484-o

A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis

Biosystems. 1995;35(1):83-92. doi: 10.1016/0303-2647(94)01484-o.

Authors

G Li¹, B Liu, Y Liu

Affiliation

¹ Institute of Theoretical Physics, Northeast Normal University, Changchun, China.

PMID: 7772725
DOI: 10.1016/0303-2647(94)01484-o

Abstract

We propose a dynamical model for the hypothalamo-pituitary-thyroid axis. This model takes into account both the interactions of hormones in this axis and the binding of thyroid hormones with proteins in plasma and tissues. It can account for the pulsatile character of hormone secretion in this axis as well as many experimental results.

MeSH terms

Animals
Feedback
Humans
Hypothalamic Hormones / metabolism
Hypothalamo-Hypophyseal System / metabolism*
Hypothalamo-Hypophyseal System / physiology
Mathematics
Models, Biological*
Pituitary Hormones / metabolism
Protein Binding
Thyroid Gland / metabolism*
Thyroid Gland / physiology
Thyroid Hormones / metabolism

Substances

Hypothalamic Hormones
Pituitary Hormones
Thyroid Hormones