Molecular genetics of neuronal survival

Curr Opin Neurobiol. 1995 Feb;5(1):42-9. doi: 10.1016/0959-4388(95)80085-9.


The past year has witnessed remarkable progress towards understanding the molecular genetics of neuronal survival. Gene-targeting experiments in mice have confirmed the long-standing idea that the nerve growth factor model of neuronal survival--that is, neuronal dependence on target-derived molecules during a critical period in development--is broadly applicable. Furthermore, a variety of biochemical and genetic techniques applied to both mammals and invertebrates have identified new genes involved in regulating cell survival during development.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor
  • Cell Cycle / physiology
  • Cell Survival / genetics*
  • Genes
  • Mice
  • Nerve Growth Factors / physiology
  • Nerve Tissue Proteins / physiology
  • Neurons / physiology*
  • Neurotransmitter Agents / genetics
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-fos / genetics
  • Proto-Oncogene Proteins c-jun / genetics
  • Transcription Factors / genetics


  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Transcription Factors