Guidance and induction of branch formation in developing axons by target-derived diffusible factors

Curr Opin Neurobiol. 1995 Feb;5(1):83-90. doi: 10.1016/0959-4388(95)80091-3.


Developing axons appear to navigate to their targets partly in response to long-range diffusible chemoattractants secreted by target cells. The past year has seen the identification of the first target-derived attractants for developing axons, the netrins. Target-derived diffusible factors have also been implicated in controlling the elaboration of axon collateral branches, and a recent study provides insight into the mechanism by which this is achieved. Evidence has also suggested neurotrophins and neurotransmitters as candidate branching and chemotropic factors.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Cell Adhesion Molecules, Neuronal / physiology
  • Nerve Growth Factors / physiology*
  • Netrin-1
  • Neurotransmitter Agents / physiology
  • Tumor Suppressor Proteins


  • Cell Adhesion Molecules, Neuronal
  • Nerve Growth Factors
  • Neurotransmitter Agents
  • Tumor Suppressor Proteins
  • Netrin-1