[The effect of succinate combined with cytochrome C on postischemic disorders in the skeletal muscle of the extremities]

Eksp Klin Farmakol. 1995 Mar-Apr;58(2):42-3.
[Article in Russian]

Abstract

A combination of succinic acid and cytochrome c was studied for effects on skeletal muscle carbohydrate metabolism in the extremities of rats with experimental arterial occlusion. The administration of the agents into the ischemic area allowed the stores of glycogen and ATP to be preserved, by lowering the activity of glucose-6-phosphate dehydrogenase and lactate dehydrogenase fraction V in the skeletal muscle of rats with extremity ischemia. The intraperitoneal administration of the agents produced no positive metabolic effect.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Cytochrome c Group / therapeutic use*
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Hindlimb / blood supply
  • Ischemia / drug therapy*
  • Ischemia / metabolism
  • Male
  • Muscle, Skeletal / blood supply*
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / metabolism
  • Rats
  • Rats, Wistar
  • Succinates / therapeutic use*
  • Succinic Acid

Substances

  • Cytochrome c Group
  • Succinates
  • Succinic Acid