Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe

Pharmacogenetics. 1995 Feb;5(1):53-7. doi: 10.1097/00008571-199502000-00007.

Authors

E S Vesell¹, T D Seaton, Y I A-Rahim

Affiliation

¹ Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033, USA.

PMID: 7773304
DOI: 10.1097/00008571-199502000-00007

No abstract available

MeSH terms

Adult
Chlorzoxazone / analogs & derivatives
Chlorzoxazone / blood
Chlorzoxazone / metabolism*
Chlorzoxazone / pharmacokinetics
Chlorzoxazone / urine
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System / genetics*
Cytochrome P-450 Enzyme System / metabolism*
Female
Genetic Variation*
Humans
Kidney / metabolism
Kinetics
Male
Middle Aged
Molecular Probes
Oxidoreductases, N-Demethylating / genetics*
Oxidoreductases, N-Demethylating / metabolism*

Substances

Molecular Probes
6-hydroxychlorzoxazone
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP2E1
Oxidoreductases, N-Demethylating
Chlorzoxazone