Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease

Curr Opin Lipidol. 1995 Apr;6(2):86-91. doi: 10.1097/00041433-199504000-00005.


Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / etiology*
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E / metabolism
  • Apolipoproteins E / pharmacology
  • Apolipoproteins E / physiology*
  • Cytoskeleton / physiology*
  • Humans
  • Neurons / metabolism
  • Neurons / ultrastructure*


  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E