Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus

Brain Res. 1995 Mar 13;674(1):104-6. doi: 10.1016/0006-8993(95)00072-x.

Abstract

In CA1-CA3 hippocampal slices, in vitro ethanol (EtOH) (10-100 mM) evoked, as a function of EtOH concentration, a differential release of aspartate (Asp) and glutamate (Glu). Omission of Ca2+ ions from the superfusion media completely abolished the EtOH-induced release of Asp but not that of Glu. In addition, at 20 mM, EtOH enhanced K(+)-evoked release only of Asp. Finally, delayed changes were observed on NMDA-evoked release of [3H]noradrenaline (NA) in the dentate gyrus (DG) after withdrawal from EtOH for 30 days.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alcohol Drinking*
  • Animals
  • Aspartic Acid / metabolism*
  • Ethanol / pharmacology*
  • Glutamic Acid / metabolism*
  • Hippocampus / metabolism*
  • In Vitro Techniques
  • Male
  • Norepinephrine / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Substances

  • Aspartic Acid
  • Ethanol
  • Glutamic Acid
  • Norepinephrine