DNA Topoisomerases

Curr Opin Struct Biol. 1995 Feb;5(1):39-47. doi: 10.1016/0959-440x(95)80007-n.


In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA Topoisomerases, Type I* / chemistry
  • DNA Topoisomerases, Type I* / metabolism
  • Humans
  • Isoenzymes* / chemistry
  • Isoenzymes* / metabolism
  • Protein Conformation


  • Isoenzymes
  • DNA Topoisomerases, Type I