The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients

Hum Pathol. 1995 Jun;26(6):668-75. doi: 10.1016/0046-8177(95)90174-4.


The histological changes in 17 biopsy specimens of the lung showing graft-versus-host disease (GVHD) in bone marrow transplant (BMT) recipients were reviewed and correlated with the patients' clinical courses. These morphological changes fell into four transplant-related categories: diffuse alveolar damage, lymphocytic bronchitis/bronchiolitis with interstitial pneumonitis, bronchiolitis obliterans organizing pneumonia, and cicatricial bronchiolitis obliterans. Pulmonary disease correlated with the presence of GVHD at extrathoracic sites. Patients with active lymphocytic bronchitis/bronchiolitis, cicatricial bronchiolitis obliterans, and diffuse alveolar damage had particularly poor outcomes. A proposal is offered for the categorization of the pulmonary damage caused by GVHD in BMT recipients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biopsy
  • Bone Marrow Transplantation / pathology*
  • Bronchitis / pathology
  • Female
  • Graft vs Host Disease / pathology*
  • Humans
  • Lung Diseases / pathology*
  • Lung Diseases, Interstitial / pathology
  • Male
  • Middle Aged
  • Pulmonary Alveoli / pathology