Prolonged bleeding time during ciprofloxacin therapy

J Clin Pharm Ther. 1995 Feb;20(1):45-6. doi: 10.1111/j.1365-2710.1995.tb00625.x.


Ciprofloxacin is a broad spectum quinolone antibiotic. Side effects reported include nausea and other gastrointestinal symptoms; skin and musculoskeletal side effects may also occur. No bleeding abnormalities or alteration in coagulation have been documented. We report a case where ciprofloxacin appeared to contribute to an idiosyncratic prolongation of bleeding time although a rechallenge 8 months later did not reproduce the effect. Moreover, subsequent investigation of the influence of ciprofloxacin on bleeding parameters in 10 healthy volunteers demonstrated no alterations in bleeding parameters.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Bleeding Time*
  • Blood Platelets / drug effects
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / adverse effects*
  • Ciprofloxacin / therapeutic use
  • Creatinine / blood
  • Escherichia coli Infections / drug therapy
  • Female
  • Humans
  • Male
  • Necrosis
  • Oliguria / pathology
  • Purpura / pathology


  • Ciprofloxacin
  • Creatinine