Change in carpal tunnel pressures that result from externally applied forces to the palm of the hand were assessed in five cadaveric specimens. MIKRO-TIP transducers were percutaneously placed into the carpal tunnel at the level of the hook of the hamate. A 1 kg force was applied to the palm of the hand in 16 separate locations. Significant elevations in carpal tunnel pressure were observed for external forces applied over the flexor retinaculum (103 mm Hg) and also for the hypothenar (37 mm Hg) and thenar (75 mm Hg) areas adjacent to the distal aspect of the carpal tunnel. These data demonstrate that the application of external forces on the palm of cadaver hands increases carpal tunnel pressure and the magnitude of the pressure change in the carpal tunnel depends on the location of the applied force.