A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis

J Pediatr. 1995 Jun;126(6):1004-7. doi: 10.1016/s0022-3476(95)70234-2.


This randomized, double-blind trial compared the efficacy of nebulized epinephrine with salbutamol in the treatment of infants with acute bronchiolitis. The mean percent oxygen saturation at 60 minutes was significantly higher in the epinephrine group. Thirty-three percent of the patients in epinephrine group were admitted to the hospital compared with 81% of the salbutamol group (p = 0.003). We conclude that nebulized epinephrine is more efficacious than salbutamol for infants with acute bronchiolitis seen in an emergency department.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aerosols
  • Albuterol / administration & dosage
  • Albuterol / therapeutic use*
  • Bronchiolitis / drug therapy*
  • Double-Blind Method
  • Epinephrine / administration & dosage
  • Epinephrine / therapeutic use*
  • Humans
  • Infant
  • Treatment Outcome


  • Aerosols
  • Albuterol
  • Epinephrine