Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in children: a case-control study

J Pediatr. 1995 Jun;126(6):940-2. doi: 10.1016/s0022-3476(95)70215-6.


A comparison of 57 cases (in children with serum calcium concentration < 2.2 mmol/L) and 171 controls (in children with serum calcium level > or = 2.2 mmol/L) was carried out to assess whether the intake of at least 1.5 L/wk of soft drinks containing phosphoric acid is a risk factor for the development of hypocalcemia. A significant association was found: odds ratio = 5.27; 95% confidence interval, 3.17 to 8.75; p < 0.001. The hypothesis of a causal relationship between intake of phosphoric acid-containing soft drinks and hypocalcemia warrants further investigation.

Publication types

  • Comparative Study

MeSH terms

  • Carbonated Beverages / adverse effects*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hypocalcemia / etiology*
  • Male
  • Odds Ratio
  • Phosphoric Acids / adverse effects*
  • Risk Factors
  • Sex Factors


  • Phosphoric Acids
  • phosphoric acid