Alpha-ketoglutarate for myocardial protection in heart surgery

Lancet. 1995 Mar 4;345(8949):552-3. doi: 10.1016/s0140-6736(95)90466-2.

Abstract

A low myocardial content of alpha-ketoglutarate during heart surgery might aggravate ischaemic injury. 24 men undergoing coronary surgery participated in a randomised controlled study. 28 g alpha-ketoglutarate was added to blood cardioplegia for intermittent antegrade intracoronary perfusion in 13 cases. alpha-ketoglutarate reduced the appearance in blood of the ischaemic markers creatine kinase MB and troponin T (at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T). These findings signify attenuated ischaemic injury, possibly secondary to enhanced myocardial oxidative capacity.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Cardioplegic Solutions / administration & dosage*
  • Cardiopulmonary Bypass
  • Coronary Artery Bypass* / adverse effects
  • Coronary Disease / surgery
  • Creatine Kinase / blood
  • Humans
  • Isoenzymes
  • Ketoglutaric Acids / administration & dosage*
  • Lactates / metabolism
  • Lactic Acid
  • Male
  • Myocardial Ischemia / prevention & control
  • Myocardium / metabolism
  • Oxygen / metabolism
  • Troponin / blood

Substances

  • Cardioplegic Solutions
  • Isoenzymes
  • Ketoglutaric Acids
  • Lactates
  • Troponin
  • Lactic Acid
  • Creatine Kinase
  • Oxygen