Controlled evaluation of a bandage contact lens and a topical nonsteroidal anti-inflammatory drug in treating traumatic corneal abrasions

Ophthalmology. 1995 Jun;102(6):979-84. doi: 10.1016/s0161-6420(95)30926-8.

Abstract

Background: Treating traumatic corneal abrasions is a common problem for the ophthalmologist. Traditional management has been the use of a pressure patch. Three different therapeutic modalities were evaluated for their efficacy in treating traumatic corneal abrasions.

Methods: Forty-seven consecutive patients with traumatic corneal abrasions were randomized prospectively in a single-masked, controlled clinical trial which compared the efficacy of (1) pressure patching, (2) a bandage contact lens, and (3) a bandage contact lens with a topical nonsteroidal anti-inflammatory drug (0.5% ketorolac tromethamine).

Results: There was no significant difference in the healing time of the three groups. However, psychometric analysis showed a significant decrease in pain in the group that received a bandage contact lens with a topical nonsteroidal anti-inflammatory drug. There was a significant difference in the ability to return to normal activities in both contact lens groups compared with the pressure-patch group. There was no significant difference among the three groups with respect to photophobia, redness, ocular irritation, headache, or tearing.

Conclusion: Use of a bandage contact lens significantly shortens the time required for a patient to return to normal activities. Moreover, addition of a nonsteroidal anti-inflammatory drug to a treatment regimen significantly decreases the pain associated with traumatic corneal abrasions. Use of a bandage contact lens with a topical nonsteroidal anti-inflammatory may prove to be an effective adjunct in treating traumatic corneal abrasions.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Bandages
  • Combined Modality Therapy
  • Contact Lenses*
  • Cornea / drug effects
  • Corneal Injuries*
  • Eye Injuries / drug therapy*
  • Female
  • Humans
  • Ketorolac Tromethamine
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Pain / drug therapy
  • Polymyxin B / administration & dosage
  • Polymyxin B / therapeutic use
  • Prospective Studies
  • Single-Blind Method
  • Tolmetin / administration & dosage
  • Tolmetin / analogs & derivatives*
  • Tolmetin / therapeutic use
  • Trimethoprim / administration & dosage
  • Trimethoprim / therapeutic use
  • Tromethamine / administration & dosage
  • Tromethamine / analogs & derivatives*
  • Tromethamine / therapeutic use
  • Wound Healing / drug effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Ophthalmic Solutions
  • Tromethamine
  • Ketorolac Tromethamine
  • Trimethoprim
  • Tolmetin
  • Polymyxin B