Mineral content of the diet alters sucrose-induced obesity in rats

Physiol Behav. 1995 Apr;57(4):659-68. doi: 10.1016/0031-9384(94)00312-2.


The effects of dietary mineral levels on caloric intake, nutrient choice, body weight, adipose tissue weight, interscapular brown adipose tissue (IBAT) weight, and thermogenic capacity, and plasma insulin and glucose levels were examined in adult male Sprague-Dawley rats. In Experiments 1 and 2, rats were fed a purified diet with zinc (Zn), chromium (Cr), and selenium (Se) added, or the same diet without the addition of these minerals. In Experiment 3, the effects of Zn and Cr were examined separately. In all experiments, half of the rats in each diet group were given a 32% sucrose solution in addition to their standard diet and water. Rats given sucrose consumed more calories and gained more weight than rats not given sucrose. However, mineral levels altered the effects of sucrose on these measures. Added minerals increased percent sucrose intake, reduced weight gain and feed efficiency, increased GDP binding in IBAT mitochondria, improved glucose tolerance, and reduced plasma insulin levels. The reduction in weight gain and increased feed efficiency found when Zn alone was added to the diet was independent of sucrose condition. In comparison, the alterations observed in these measures when Cr alone was added to the diet varied as a function of sucrose availability.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue / drug effects
  • Adipose Tissue, Brown / drug effects
  • Animals
  • Chromium / pharmacology
  • Diet*
  • Drinking / drug effects
  • Eating / drug effects
  • Glucose Tolerance Test
  • Guanosine Diphosphate / metabolism
  • Insulin / blood
  • Male
  • Minerals / pharmacology*
  • Obesity / physiopathology*
  • Organ Size / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Selenium / pharmacology
  • Sucrose / pharmacology*
  • Weight Gain / drug effects
  • Zinc / pharmacology


  • Insulin
  • Minerals
  • Chromium
  • Guanosine Diphosphate
  • Sucrose
  • Selenium
  • Zinc