Ethiopian visceral leishmaniasis patients co-infected with human immunodeficiency virus

Trans R Soc Trop Med Hyg. Mar-Apr 1995;89(2):205-7. doi: 10.1016/0035-9203(95)90497-2.

Abstract

This communication reports 7 Ethiopian visceral leishmaniasis (VL) patients co-infected with human immunodeficiency virus (HIV). The clinical and laboratory findings in 6 patients did not differ from classical VL. All patients had highly elevated anti-leishmanial antibody titres, determined by immunoglobulin G-based enzyme-linked immunosorbent assay; they most probably acquired the Leishmania infection before HIV. Amastigotes were identified in the splenic aspirates of 6 patients and in the lymph node aspirate of the 2 patients whose lymph nodes were examined. The CD4:CD8 lymphocyte ratio was depressed in those patients whose ratio was determined. Most patients showed some initial response to pentavalent antimonial therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Antibodies, Protozoan / analysis
  • CD4-CD8 Ratio
  • Ethiopia
  • HIV Infections / complications*
  • Humans
  • Leishmania / isolation & purification
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / immunology
  • Lymph Nodes / parasitology
  • Male
  • Spleen / parasitology

Substances

  • Antibodies, Protozoan