Role of endothelin in the exercise intolerance of chronic heart failure

Am J Cardiol. 1995 Jun 15;75(17):1282-3. doi: 10.1016/s0002-9149(99)80783-8.


In conclusion, plasma levels of the endothelial-derived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.

MeSH terms

  • Adult
  • Aged
  • Endothelins / blood*
  • Exercise Tolerance*
  • Heart Failure / blood
  • Heart Failure / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine / blood
  • Oxygen Consumption
  • Pulmonary Gas Exchange
  • Vasopressins / blood


  • Endothelins
  • Vasopressins
  • Norepinephrine