Dopamine transporter gene polymorphism and alcoholism

Biochem Biophys Res Commun. 1995 Jun 6;211(1):28-32. doi: 10.1006/bbrc.1995.1773.


In this search for a possible association between the dopamine transporter gene (DAT1) polymorphism and alcoholism, 655 Japanese alcoholics were grouped according to their aldehyde dehydrogenase-2 (ALDH2) genotypes. Because inactive ALDH2 is an established negative risk factor for alcoholism, alcoholics with the mutant allele, ALDH2*2, were considered a relatively homogeneous group. The frequency of the 7-repeat allele of the DAT1 variable number of tandem repeat was significantly higher in alcoholics with ALDH2*2 than in control subjects. These results are consistent with the hypothesis that alteration in the dopaminergic system plays some role in the development of alcoholism.

Publication types

  • Comparative Study

MeSH terms

  • Alcoholism / enzymology
  • Alcoholism / genetics*
  • Aldehyde Dehydrogenase / genetics*
  • Alleles
  • Base Sequence
  • Carrier Proteins / genetics*
  • DNA / blood
  • DNA / genetics
  • DNA Primers
  • Dopamine Plasma Membrane Transport Proteins
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Middle Aged
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Reference Values


  • Carrier Proteins
  • DNA Primers
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A3 protein, human
  • DNA
  • Aldehyde Dehydrogenase