Telomere shortening in chronic liver diseases

Biochem Biophys Res Commun. 1995 Jun 6;211(1):33-9. doi: 10.1006/bbrc.1995.1774.

Abstract

We measured the telomere length in patients with chronic hepatitis or liver cirrhosis and found a significant telomere shortening in the liver with chronic liver disease compared to that in the normal liver. The telomere length tended to decrease with the progression of chronic liver disease.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aging / physiology*
  • Base Sequence
  • Blotting, Southern
  • Female
  • Hepatitis / genetics*
  • Hepatitis / pathology
  • Humans
  • Liver / cytology
  • Liver / metabolism
  • Liver / pathology
  • Liver Cirrhosis / genetics*
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Reference Values
  • Telomere / pathology
  • Telomere / ultrastructure*

Substances

  • Oligonucleotide Probes