Osteoporosis in rheumatoid arthritis. A monozygotic co-twin control study

Arthritis Rheum. 1995 Jun;38(6):806-9. doi: 10.1002/art.1780380614.


Objective: To quantify the magnitude and distribution of osteoporosis in rheumatoid arthritis (RA).

Methods: Bone mineral density (BMD) was measured by dual x-ray absorptiometry, in a monozygotic co-twin control study.

Results: BMD was reduced at most skeletal sites in the twin with RA compared with the co-twin (lumbar spine 4.6%, femoral neck 9.7%, total body 5.7%). Differences in lean soft tissue (5.6% for total body) correlated with differences in BMD between twins at multiple sites.

Conclusion: Osteoporosis in RA is generalized and may be related to loss of mobility or muscle mass associated with the disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / epidemiology*
  • Arthritis, Rheumatoid / genetics
  • Bone Density / physiology
  • Diseases in Twins / epidemiology*
  • Diseases in Twins / genetics
  • Female
  • Femur Neck / pathology
  • Femur Neck / physiopathology
  • Humans
  • Lumbar Vertebrae / pathology
  • Lumbar Vertebrae / physiopathology
  • Male
  • Osteoporosis / complications
  • Osteoporosis / epidemiology*
  • Osteoporosis / genetics
  • Registries
  • Regression Analysis
  • Surveys and Questionnaires
  • Twins, Monozygotic*
  • United Kingdom / epidemiology