Primary malignant melanoma of meninges: atypical presentation of subacute meningitis

Pediatr Neurol. 1995 Feb;12(2):172-4. doi: 10.1016/0887-8994(94)00155-u.


Primary malignant melanoma of the meninges is described in a 5-year-old boy who presented with a 3-month history suggestive of subacute meningitis. Clinically the diagnosis of tuberculous meningitis was made and antituberculous treatment was begun. Despite this treatment, the patient's condition continued to deteriorate. Through cytologic examination of the cerebrospinal fluid malignant melanoma cells were identified, emphasizing the importance of this investigation in children with atypical meningitis. The diagnosis of malignant melanoma of the meninges was confirmed on brain biopsy.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Child, Preschool
  • Diagnostic Errors
  • Humans
  • Male
  • Melanoma / diagnosis*
  • Melanoma / pathology
  • Meningeal Neoplasms / diagnosis*
  • Meningeal Neoplasms / pathology
  • Neurologic Examination
  • Temporal Lobe / pathology
  • Tuberculosis, Meningeal / diagnosis*
  • Tuberculosis, Meningeal / pathology