NMR studies of acetan and the related bacterial polysaccharide, CR1/4, produced by a mutant strain of Acetobacter xylinum

Carbohydr Res. 1995 Apr 19;269(2):319-31. doi: 10.1016/0008-6215(94)00367-o.

Abstract

Acetan is a bacterial polysaccharide produced by Acetobacter xylinum NRRL B42. Chemical mutagenesis of A.xylinum allowed selection of a mutant strain which produced a new polysaccharide, CR1/4. 2D NMR methods have been used to assign the 1H and 13C spectra of the two polysaccharides and to determine that CR1/4 has the structure shown below. The total number of O-acetyl groups is slightly less than two per repeating unit. [formula: see text] The pentasaccharide side chain of acetan is truncated to a disaccharide unit in CR1/4, but the structures are otherwise identical. In particular, the degree of acetylation is about the same and the O-acetyl groups are located at the same position in both polysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrate Sequence
  • Gluconacetobacter xylinus / chemistry*
  • Gluconacetobacter xylinus / genetics
  • Gluconacetobacter xylinus / metabolism
  • Glucose / chemistry
  • Glucuronates / analysis
  • Glucuronic Acid
  • Magnetic Resonance Spectroscopy
  • Mannose / analysis
  • Molecular Sequence Data
  • Mutagenesis
  • Polysaccharides, Bacterial / biosynthesis
  • Polysaccharides, Bacterial / chemistry*

Substances

  • Glucuronates
  • Polysaccharides, Bacterial
  • acetan
  • Glucuronic Acid
  • Glucose
  • Mannose