The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

Cell. 1995 Jun 16;81(6):957-66. doi: 10.1016/0092-8674(95)90015-2.


Mutations in the APC gene are responsible for various familial and sporadic colorectal cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop multiple adenomas throughout their small and large intestine. Quantitative trait loci studies have identified a locus, Mom1, which maps to the distal region of chromosome 4, that dramatically modifies Min-induced tumor number. We report here the identification of a candidate gene for Mom1. The gene for secretory type II phospholipase A2 (Pla2s) maps to the same region that contains Mom1 and displays 100% concordance between allele type and tumor susceptibility. Expression and sequence analysis revealed that Mom1 susceptible strains are most likely null for Pla2s activity. Our results indicate that Pla2s acts as a novel gene that modifies polyp number by altering the cellular microenvironment within the intestinal crypt.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenomatous Polyposis Coli / enzymology
  • Adenomatous Polyposis Coli / etiology
  • Adenomatous Polyposis Coli / genetics
  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Crosses, Genetic
  • DNA, Complementary / genetics
  • Female
  • Gene Expression
  • Genes, APC*
  • Genes, Dominant
  • Intestinal Neoplasms / enzymology*
  • Intestinal Neoplasms / etiology
  • Intestinal Neoplasms / genetics*
  • Male
  • Mice
  • Mice, Inbred AKR
  • Mice, Mutant Strains
  • Models, Biological
  • Molecular Sequence Data
  • Muridae
  • Mutation
  • Phospholipases A / genetics*
  • Phospholipases A / physiology
  • Phospholipases A2
  • Polymorphism, Restriction Fragment Length
  • Rats


  • DNA, Complementary
  • Phospholipases A
  • Phospholipases A2

Associated data

  • GENBANK/U28244