Pulmonary capillaritis and alveolar hemorrhage associated with the antiphospholipid antibody syndrome

J Rheumatol. 1995 Mar;22(3):554-6.


Pulmonary hemorrhage due to small vessel vasculitis is a well recognized complication of many autoimmune and collagen vascular disorders. The antiphospholipid antibody syndrome (APS) is a disorder associated with hypercoagulability, thrombocytopenia, and thromboembolic phenomena. Pulmonary manifestations include pulmonary embolism, pulmonary hypertension, and respiratory failure associated with diffuse pulmonary infiltrates. We describe a patient with the APS syndrome, without systemic lupus erythematosus, who developed pulmonary hemorrhage due to pulmonary capillaritis with evidence of perivascular immune complex deposition.

Publication types

  • Case Reports

MeSH terms

  • Antigen-Antibody Complex / analysis
  • Antiphospholipid Syndrome / complications*
  • Capillaries
  • Female
  • Hemorrhage / complications*
  • Hemorrhage / diagnostic imaging
  • Hemorrhage / pathology
  • Humans
  • Lung / immunology
  • Lung / pathology
  • Lung Diseases / complications
  • Lung Diseases / diagnostic imaging
  • Lung Diseases / pathology
  • Middle Aged
  • Pulmonary Alveoli*
  • Pulmonary Circulation*
  • Radiography, Thoracic
  • Vasculitis / complications*


  • Antigen-Antibody Complex