Fatty acyl CoA esters as regulators of cell metabolism

Prostaglandins Leukot Essent Fatty Acids. Feb-Mar 1995;52(2-3):163-6. doi: 10.1016/0952-3278(95)90016-0.

Abstract

Long chain fatty acyl CoA esters have the ability to interact with certain proteins and thereby serve as effectors in cell metabolism. In particular, they can displace nucleotides from specific nucleotide dependent or binding proteins and interfere with their action. The ADP/ATP carrier and uncoupling protein are two examples where the interplay of nucleotide and acyl CoA binding to the proteins regulate their function. Other proteins such as glucokinase can be considered in this group. In certain tissues like liver they are affected during fasting and insulin deficiency, and when serum fatty acids and liver acyl CoA levels are elevated. More recently, an acyl CoA binding protein in E. coli has been found to be a transcription factor for gene regulation of fatty acid metabolism enzymes. There appears to be some consensus in the amino acid sequence for acyl CoA binding sites on these proteins which serve a variety of important roles in cellular metabolism.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acyl Coenzyme A / metabolism*
  • Animals
  • Binding Sites
  • Carrier Proteins / metabolism
  • Consensus Sequence
  • Ion Channels
  • Membrane Proteins / metabolism
  • Mitochondria, Liver / metabolism*
  • Mitochondrial ADP, ATP Translocases / metabolism
  • Mitochondrial Proteins
  • Palmitic Acids / pharmacology
  • Palmitoyl Coenzyme A / pharmacology
  • Proton Pumps / drug effects
  • Rats
  • Uncoupling Protein 1

Substances

  • Acyl Coenzyme A
  • Carrier Proteins
  • Ion Channels
  • Membrane Proteins
  • Mitochondrial Proteins
  • Palmitic Acids
  • Proton Pumps
  • Uncoupling Protein 1
  • Palmitoyl Coenzyme A
  • Mitochondrial ADP, ATP Translocases