Lung cancer: reproducibility of quantitative measurements for evaluating 2-[F-18]-fluoro-2-deoxy-D-glucose uptake at PET

Radiology. 1995 Jul;196(1):167-73. doi: 10.1148/radiology.196.1.7784562.


Purpose: To study the precision of repeated 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake measurements at positron emission tomography (PET) in patients with primary lung cancer.

Materials and methods: Ten patients with untreated lung cancer underwent two dynamic FDG PET examinations after a 4-hour fast within 1 week. Kinetic modeling of tumor FDG uptake was performed on the basis of a three-compartment model. The tumor concentration of F-18 (standardized uptake value calculated on the basis of predicted lean body mass [SUV-lean]) was also measured 50-60 minutes after injection of a tracer. Blood glucose, insulin, and free fatty acid levels were monitored.

Results: SUV-lean and the FDG influx constant Ki were measured with a mean +/- standard deviation difference of 10% +/- 7 and 10% +/- 8, respectively, over repeated PET scans. The mean difference was reduced to 6% +/- 6 and 6% +/- 5 by multiplying SUV-lean and Ki by plasma glucose concentration.

Conclusion: SUV-lean and graphical Ki can be measured reproducibly, supporting their use in quantitative FDG PET algorithms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • Deoxyglucose / analogs & derivatives*
  • Fatty Acids, Nonesterified / blood
  • Female
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Humans
  • Insulin / analysis
  • Lung Neoplasms / blood
  • Lung Neoplasms / diagnostic imaging*
  • Male
  • Middle Aged
  • Observer Variation
  • Tomography, Emission-Computed*


  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Fluorine Radioisotopes
  • Insulin
  • Fluorodeoxyglucose F18
  • Deoxyglucose