Bronchiectasis and homozygous (P1ZZ) alpha 1-antitrypsin deficiency in a young man

Thorax. 1995 Apr;50(4):424-5. doi: 10.1136/thx.50.4.424.


Pulmonary complications of alpha 1-antitrypsin deficiency are most commonly manifested by panlobular emphysema. This report describes histologically proven bronchiectasis in a 21 year old man with massive haemoptysis and homozygous deficiency of alpha 1-antitrypsin. Neither panlobular emphysema nor cirrhosis of the liver were present. Bronchiectasis must be considered part of the spectrum of the pulmonary pathology that may be encountered in individuals with alpha 1-antitrypsin deficiency.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bronchiectasis / etiology*
  • Bronchiectasis / pathology
  • Hemoptysis / etiology
  • Hemoptysis / pathology
  • Humans
  • Male
  • Phenotype
  • alpha 1-Antitrypsin Deficiency*