Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome

Am J Ophthalmol. 1995 Jun;119(6):796-8. doi: 10.1016/s0002-9394(14)72788-6.


Purpose/methods: We conducted this study to determine if the herpesviruses are possible etiologic agents in Posner-Schlossman syndrome. We aspirated aqueous humor samples from patients during acute attacks of the syndrome. Ten normal aqueous humor specimens from patients undergoing cataract surgery were used as controls. DNA was extracted and subjected to polymerase chain reaction amplification and Southern blot hybridization.

Results/conclusion: All three specimens were positive for amplified genomic fragments of herpes simplex virus and negative for varicella-zoster virus and cytomegalovirus. Ten normal aqueous specimens were negative for all three. Herpes simplex virus may play a role in the origin of Posner-Schlossman syndrome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Aqueous Humor / chemistry
  • Blotting, Southern
  • Cytomegalovirus / genetics
  • DNA, Viral / analysis
  • Female
  • Herpesvirus 1, Human / genetics
  • Herpesvirus 1, Human / isolation & purification
  • Herpesvirus 3, Human / genetics
  • Humans
  • Iridocyclitis / etiology*
  • Keratitis, Herpetic / complications*
  • Keratitis, Herpetic / pathology
  • Ocular Hypertension / etiology*
  • Polymerase Chain Reaction
  • Syndrome


  • DNA, Viral