Selenium and magnesium status in fibromyalgia

Magnes Res. 1994 Dec;7(3-4):285-8.


Muscle pain has been associated with magnesium (Mg) and selenium (Se) deficiency: magnesium and selenium status were investigated in fibromyalgia (FM). Erythrocyte (E), leucocyte (L) and serum (S) magnesium, serum selenium and zinc, and vitamin B1, B2, A or E status were assessed in 22 patients with fibromyalgia and in 23 age-matched healthy controls. LMg is significantly increased (P < 0.05) and EMg slightly decreased in fibromyalgia. These magnesium abnormalities are associated with previously-reported impairment of thiamin metabolism. Antioxidant status (as well as plasma malondialdehyde) is unchanged in fibromyalgia and serum selenium levels, slightly but not significantly correlated with serum magnesium, is normal.

MeSH terms

  • Adult
  • Erythrocytes / chemistry
  • Female
  • Fibromyalgia / blood*
  • Glutathione Reductase / blood
  • Humans
  • Leukocytes / chemistry
  • Magnesium / blood*
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Retrospective Studies
  • Selenium / blood*
  • Vitamins / blood
  • Zinc / blood


  • Vitamins
  • Malondialdehyde
  • Glutathione Reductase
  • Selenium
  • Magnesium
  • Zinc