Correlation between serum pepsinogen concentration and gastric acidity measured by 24 h pH monitoring

J Gastroenterol Hepatol. 1995 Mar-Apr;10(2):152-7. doi: 10.1111/j.1440-1746.1995.tb01070.x.


The relationship between the intragastric pH measured by 24 h pH monitoring system and the serum pepsinogen I/II ratio was studied in 68 cases. When pepsinogen I/II ratio was compared with pH 3.0 holding time (the percentage time during which the gastric pH is above 3.0), there was a negative correlation between these two parameters (correlation coefficient r = -0.62, P < 0.001). Furthermore, there was also a strong negative correlation between the early morning (from 03.00 to 06.00 h) gastric pH and pepsinogen I/II ratio (r = -0.76, P < 0.001). Accordingly, by simply measuring serum pepsinogen I and II, it may be possible to infer gastric acidity and to obtain the information concerning the early morning intragastric pH.

MeSH terms

  • Female
  • Gastric Acidity Determination*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Monitoring, Physiologic*
  • Pepsinogens / blood*


  • Pepsinogens