Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis

Biosci Biotechnol Biochem. 1995 May;59(5):831-3. doi: 10.1271/bbb.59.831.

Abstract

One of the major allergenic proteins in the soybean 7S-globulin fraction, which was recognized by sera of about 25% soybean-sensitive patients with atopic dermatitis, was identified as alpha-subunit of beta-conglycinin. The IgE antibodies recognizing the alpha-subunit did not show a cross-reactivity against both alpha'- and beta-subunits known to be highly homologous to alpha-subunit, and also against other allergenic components identified in soybeans [Ogawa et al., J. Nutr. Sci. Vitaminol., 35, 555-565 (1993)]. The IgE-binding site(s) was estimated to be located on the peptide 232-283 of alpha-subunit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Allergens / immunology
  • Antibodies, Anti-Idiotypic / immunology*
  • Antigens, Plant
  • Child
  • Child, Preschool
  • Chymotrypsin / chemistry
  • Chymotrypsin / metabolism
  • Cyanogen Bromide / chemistry
  • Cyanogen Bromide / metabolism
  • Dermatitis, Atopic / complications
  • Dermatitis, Atopic / immunology*
  • Globulins / chemistry
  • Globulins / immunology*
  • Globulins / metabolism
  • Humans
  • Hypersensitivity / complications
  • Hypersensitivity / immunology*
  • Immunoglobulin E / immunology*
  • Infant
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Plant Proteins / immunology
  • Seed Storage Proteins
  • Soybean Proteins*
  • Soybeans / immunology*

Substances

  • Allergens
  • Antibodies, Anti-Idiotypic
  • Antigens, Plant
  • Globulins
  • Peptide Fragments
  • Plant Proteins
  • Seed Storage Proteins
  • Soybean Proteins
  • beta-conglycinin protein, Glycine max
  • Immunoglobulin E
  • Chymotrypsin
  • Cyanogen Bromide