Rechallenge with lamotrigine after initial rash

Seizure. 1995 Mar;4(1):67-71. doi: 10.1016/s1059-1311(05)80082-2.


Eight patients rechallenged with lamotrigine after initial exposure which resulted in a skin rash are reported. On reintroduction of the lamotrigine, six of the patients had no recurrence of the rash. Of the other two patients, one had the occurrence of a mild fluctuating and qualitatively different skin rash on rechallenge. The other patient had developed a dose-related rash on initial challenge resulting in a dose reduction. The first attempt to re-increase the dose resulted in reappearance of the rash which again disappeared on dose reduction. However a further attempt to re-increase the dose did not result in reappearance of a rash. It is suggested that patients who experience a rash but good therapeutic response to lamotrigine might be considered for re-dosing.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / adverse effects*
  • Child
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Eruptions / diagnosis*
  • Drug Therapy, Combination
  • Epilepsy / drug therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Lamotrigine
  • Male
  • Middle Aged
  • Recurrence
  • Triazines / administration & dosage
  • Triazines / adverse effects*


  • Anticonvulsants
  • Triazines
  • Lamotrigine