[Detection of nicotine in eccrine sweat after stimulation of sweat glands during nicotine withdrawal]

Hautarzt. 1995 Apr;46(4):255-8. doi: 10.1007/s001050050250.
[Article in German]


The presence of nicotine in sweat obtained from smokers and one non-smoker exposed to tobacco smoke after 4 h to 8 days of nicotine-free time was investigated. Following stimulation of the eccrine glands, sweat samples were taken every hour for 6 h. The total nicotine concentrations, i.e. the sum of nicotine and its metabolites, were determined by radioimmunoassay. The presence of unchanged nicotine was revealed by gas chromatography/mass spectrometry.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Cotinine / pharmacokinetics
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Male
  • Metabolic Clearance Rate / physiology
  • Middle Aged
  • Nicotine / adverse effects*
  • Nicotine / pharmacokinetics*
  • Pilocarpine
  • Smoking Cessation*
  • Substance Withdrawal Syndrome / diagnosis
  • Substance Withdrawal Syndrome / metabolism*
  • Tobacco Smoke Pollution


  • Tobacco Smoke Pollution
  • Pilocarpine
  • Nicotine
  • Cotinine