CT-guided pleural needle biopsy in the diagnosis of malignant mesothelioma

J Comput Assist Tomogr. May-Jun 1995;19(3):370-4. doi: 10.1097/00004728-199505000-00006.


Objective: Our goal was to determine the sensitivity of CT-guided closed pleural needle biopsy (CPNB) for the histopathologic diagnosis of diffuse malignant pleural mesothelioma (DMPM).

Materials and methods: Thirty patients with DMPM were studied with CT-guided CPNB. Tumor specimens were classified according to their cell types.

Results: In 25 (83.3%) patients, the diagnosis was made by CT-guided CPNB. The remaining five patients were diagnosed by thoracoscopy, thoracotomy, or excisional biopsy of the chest wall mass. Pneumothorax was observed in 9.5% of patients and local seeding of tumor in 21.7% of patients who underwent CPNB.

Conclusion: Properly performed CPNB under CT guidance may yield an increased sensitivity for the diagnosis of diffuse malignant pleural mesothelioma.

MeSH terms

  • Adult
  • Aged
  • Biopsy, Needle / methods
  • Female
  • Humans
  • Male
  • Mesothelioma / diagnostic imaging*
  • Mesothelioma / pathology*
  • Middle Aged
  • Pleural Neoplasms / diagnostic imaging*
  • Pleural Neoplasms / pathology*
  • Prospective Studies
  • Tomography, X-Ray Computed / methods*