Med Clin North Am. 1995 Jul;79(4):789-801. doi: 10.1016/s0025-7125(16)30039-6.


Tetracyclines are relatively safe drugs with a broad antimicrobial spectrum. Doxycycline remains the preferred tetracycline agent for most indications. Doxycycline has a long half-life, which makes convenient twice-a-day dosing possible. It is well absorbed orally even in the presence of food, has excellent tissue penetration, and does not require a dose adjustment in renal insufficiency. Doxycycline is a useful agent for the treatment of atypical pneumonias, sexually transmitted diseases, traveler's diarrhea, rickettsial infections, and Lyme disease. Minocycline is the preferred drug for MRSA colonization/infection.

Publication types

  • Review

MeSH terms

  • Bacterial Infections / drug therapy*
  • Humans
  • Microbial Sensitivity Tests
  • Tetracycline Resistance
  • Tetracyclines* / adverse effects
  • Tetracyclines* / pharmacokinetics
  • Tetracyclines* / therapeutic use


  • Tetracyclines