Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy

Lancet. 1995 Jun 17;345(8964):1540-2. doi: 10.1016/s0140-6736(95)91088-3.


We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42 years) and to require renal replacement therapy at a younger age (medians 37, 42, and 48 years, respectively). The rate of progression was significantly worse in patients homozygous for the D allele. The DD genotype is associated with increased severity of disease in patients with IgA nephropathy.

MeSH terms

  • Adult
  • Alleles
  • Base Sequence
  • Blood Pressure / physiology
  • Creatinine / blood
  • DNA / genetics
  • DNA Primers
  • Genotype
  • Glomerulonephritis, IGA / genetics*
  • Glomerulonephritis, IGA / physiopathology
  • Humans
  • Introns
  • Middle Aged
  • Molecular Sequence Data
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic
  • Retrospective Studies


  • DNA Primers
  • DNA
  • Creatinine
  • Peptidyl-Dipeptidase A