Polarization of both major body axes in Drosophila by gurken-torpedo signalling

Nature. 1995 Jun 22;375(6533):654-8. doi: 10.1038/375654a0.

Abstract

Anterior-posterior polarity in Drosophila arises from the movement of the oocyte to the posterior of the egg chamber, and the subsequent acquisition of posterior fate by the adjacent somatic follicle cells. We demonstrate that gurken is necessary in the oocyte and torpedo/DER in the follicle cells for the induction of posterior fate. As the gurken-torpedo/DER pathway also establishes dorsoventral polarity later in oogenesis, Drosophila uses the same germline to soma signalling pathway to determine both embryonic axes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Polarity
  • Drosophila / embryology*
  • Drosophila / genetics
  • Drosophila / physiology
  • Drosophila Proteins*
  • Embryonic Induction / physiology*
  • ErbB Receptors / physiology*
  • Female
  • Insect Hormones / physiology*
  • Male
  • Mutation
  • Oocytes / physiology
  • Ovarian Follicle / physiology
  • Protein Kinases*
  • Receptors, Invertebrate Peptide / physiology*
  • Signal Transduction
  • Transforming Growth Factor alpha*
  • Transforming Growth Factors / physiology*

Substances

  • Drosophila Proteins
  • Insect Hormones
  • Receptors, Invertebrate Peptide
  • Transforming Growth Factor alpha
  • grk protein, Drosophila
  • Transforming Growth Factors
  • Protein Kinases
  • Egfr protein, Drosophila
  • ErbB Receptors