The remarkable coding strategy of borna disease virus: a new member of the nonsegmented negative strand RNA viruses

Virology. 1995 Jun 20;210(1):1-8. doi: 10.1006/viro.1995.1311.

Abstract

BDV uses a remarkably broad range of mechanisms to direct expression of its 8.9-kb genome. Although much remains to be elucidated, it is clear that BDV genome expression is modulated by the use of multiple strategies, including differential gene transcription, post-transcriptional modification, and translational efficiency. Further insights into the details of this multilevel system will be essential to understanding BDV biology, pathogenesis, and neurotropism.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Borna disease virus / genetics*
  • Consensus Sequence
  • Gene Expression
  • Genome, Viral
  • Humans
  • Molecular Sequence Data
  • Open Reading Frames
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional
  • RNA Splicing
  • RNA Viruses / genetics*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / metabolism
  • Regulatory Sequences, Nucleic Acid
  • Terminator Regions, Genetic
  • Transcription, Genetic
  • Viral Proteins / biosynthesis
  • Viral Proteins / genetics

Substances

  • RNA, Messenger
  • Viral Proteins