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Clinical Trial
, 152 (7), 1084-6

Double-blind, Placebo-Controlled, Crossover Trial of Inositol Treatment for Panic Disorder

Affiliations
Clinical Trial

Double-blind, Placebo-Controlled, Crossover Trial of Inositol Treatment for Panic Disorder

J Benjamin et al. Am J Psychiatry.

Abstract

Objective: Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.

Method: Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.

Results: The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.

Conclusions: The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.

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