Relapsing bilateral uveitis and papilledema in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)

Eur J Ophthalmol. 1995 Jan-Mar;5(1):59-62.


Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-hereditary histiocytic proliferative disorder affecting young people, with extranodal manifestations in 28-43% of cases. Eye involvement is infrequent. Lymphoproliferation in the soft tissues of the orbit and in the lids has been reported in 12% of cases but intraocular involvement is rare. We describe the case of a 12-year-old boy affected by Rosai-Dorfman disease with bilateral relapsing uveitis and papilledema that appeared four years before the onset of lymphadenopathy.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Histiocytes / chemistry
  • Histiocytes / pathology
  • Histiocytosis, Sinus / complications*
  • Histiocytosis, Sinus / pathology
  • Humans
  • Immunoenzyme Techniques
  • Lymph Nodes / chemistry
  • Lymph Nodes / pathology
  • Lymphocytes / pathology
  • Male
  • Papilledema / etiology*
  • Recurrence
  • S100 Proteins / analysis
  • Uveitis / etiology*


  • S100 Proteins