Basement membrane (type IV) collagen

Matrix Biol. 1995 Feb;14(6):439-45. doi: 10.1016/0945-053x(95)90001-2.

Abstract

The collagen IV molecule is 400 nm long and consists of two alpha 1 (IV) and one alpha 2 (IV) chains. Their genes COL4A1 and COL4A2 form a transcription unit in which they are arranged head-to-head and connected by a short common promoter region. Recently, four additional genes have been discovered. They are similarly arranged in the pairs COL4A3-A4 and COL4A5-A6 and code for additional collagen IV isoforms. in the macromolecular network of collagen IV, which provides the scaffold for basement membranes, the molecules are attached and cross-linked via their like end-regions and they interact laterally with their triple-helical domains in a not yet fully understood manner. Collagen IV is involved in interactions with cells and possesses two specific recognition sites for the integrins alpha 1 beta 1 and alpha 2 beta 1.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Basement Membrane / chemistry*
  • Cell Adhesion
  • Collagen / chemistry*
  • Collagen / genetics
  • Collagen / physiology
  • Genes
  • Humans
  • Macromolecular Substances
  • Microscopy, Electron
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Protein Conformation

Substances

  • Macromolecular Substances
  • Collagen