Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome

Adv Neuroimmunol. 1995;5(1):39-56. doi: 10.1016/0960-5428(94)00048-s.


The justification for disordered chronobiology for fibromyalgia and chronic fatigue syndrome (CFS) is based on the following evidence: The studies on disordered sleep physiology and the symptoms of fibromyalgia and CFS; the experimental studies that draw a link between interleukin-1 (IL-1), immune-neuroendocrine-thermal systems and the sleep-wake cycle; studies and preliminary data of the inter-relationships of sleep-wakefulness, IL-1, and aspects of peripheral immune and neuroendocrine functions in healthy men and in women during differing phases of the menstrual cycle; and the observations of alterations in the immune-neuroendocrine functions of patients with fibromyalgia and CFS (Moldofsky, 1993b, d). Time series analyses of measures of the circadian pattern of the sleep-wake behavioural system, immune, neuroendocrine and temperature functions in patients with fibromyalgia and CFS should determine whether alterations of aspects of the neuro-immune-endocrine systems that accompany disordered sleep physiology result in nonrestorative sleep, pain, fatigue, cognitive and mood symptoms in patients with fibromyalgia and CFS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Temperature Regulation
  • Circadian Rhythm / physiology
  • Cytokines / physiology
  • Electroencephalography
  • Fatigue Syndrome, Chronic / etiology
  • Fatigue Syndrome, Chronic / physiopathology*
  • Female
  • Fibromyalgia / etiology
  • Fibromyalgia / physiopathology*
  • Humans
  • Infections / complications
  • Infections / immunology
  • Interleukin-1 / physiology*
  • Male
  • Models, Neurological
  • Neuroimmunomodulation*
  • Neuropeptides / physiology
  • Neurosecretory Systems / physiopathology*
  • Rats
  • Sleep Stages / physiology
  • Sleep Wake Disorders / complications*
  • Sleep Wake Disorders / immunology


  • Cytokines
  • Interleukin-1
  • Neuropeptides