Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress

Brain Res. 1995 Mar 27;675(1-2):325-8. doi: 10.1016/0006-8993(95)00013-g.


A microdialysis probe was placed in either the shell or core compartment of the nucleus accumbens and rats were exposed to mild footshock. Extracellular dopamine levels in the shell of the nucleus accumbens were elevated during the 20-min collection period immediately after discontinuing footshock. In contrast, the levels of dopamine remained unaltered in the core of the nucleus accumbens.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Dopamine / metabolism
  • Dopamine / physiology*
  • Electroshock
  • Extracellular Space / metabolism
  • Male
  • Microdialysis
  • Nucleus Accumbens / anatomy & histology
  • Nucleus Accumbens / metabolism
  • Nucleus Accumbens / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Stress, Psychological / metabolism
  • Stress, Psychological / physiopathology*
  • Synaptic Transmission / physiology*


  • Dopamine