Seronegative chronic relapsing neuroborreliosis

Eur Neurol. 1995;35(2):113-7. doi: 10.1159/000117104.


We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Bacterial / cerebrospinal fluid
  • Antigen-Antibody Reactions*
  • Chronic Disease
  • Female
  • Humans
  • Lyme Disease / drug therapy
  • Lyme Disease / immunology*
  • Middle Aged
  • Nervous System Diseases / drug therapy
  • Nervous System Diseases / immunology*
  • Recurrence


  • Anti-Bacterial Agents
  • Antibodies, Bacterial