The pathogenesis of hypertrophic/keloid scarring

Int J Oral Maxillofac Surg. 1994 Aug;23(4):232-6. doi: 10.1016/s0901-5027(05)80377-7.

Abstract

The formation of hypertrophic and keloid scars after cutaneous wounding is of particular relevance to the practice of maxillofacial surgery. This paper reviews current knowledge of the local and systemic factors underlying the formation of these scars and outlines the current and potential treatment modalities for these lesions.

Publication types

  • Review

MeSH terms

  • Cicatrix, Hypertrophic / etiology*
  • Cicatrix, Hypertrophic / metabolism
  • Cicatrix, Hypertrophic / therapy
  • Collagen / metabolism
  • Cytokines / metabolism
  • Extracellular Matrix / metabolism
  • Facial Injuries / complications
  • Humans
  • Interleukin-1 / metabolism
  • Keloid / etiology*
  • Keloid / metabolism
  • Keloid / therapy
  • Transforming Growth Factor beta / metabolism
  • Wound Healing / immunology
  • Wound Healing / physiology

Substances

  • Cytokines
  • Interleukin-1
  • Transforming Growth Factor beta
  • Collagen